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Even though, conventional cancer therapies, comprising surgery and chemo-and radiotherapy, play an important role in the treatment of most solid tumours, successful therapeutic outcome is frequently limited due to high toxicity and related side-effects, as well as the development of multi-drug resistances.Therefore, there is need for new therapeutic strategies not only to obtain higher treatment efficacy, but also for the reduction of toxicity and adverse effects.Emerging evidence suggests that combining cancer preventive agents with chemotherapy or radiotherapy may lead to enhanced antitumor activity through synergistic action or compensation of inverse properties.