论文部分内容阅读
Robust rules of activity-induced synaptic plasticity are believed to be important for learning in neural circuits.However, these rules can take quantitatively and qualitatively different forms under different context of extrinsic and intrinsic modulation.In cultured hippocampal neurons, the presence of neuromodulator dopamine can dramatically enhance the sensitivity of STDP while reducing its temporal contrast, probably through interaction between D 1 receptor and NMDA receptor signaling pathways.In the absence of exogenous modulators,the history network activity of different timescales appears to alter the capacity as well as the molecular mediators of synaptic plasticity in a neuronal circuit.Furthermore, synaptic plasticity rules characterized in vivo can be shifted by severe stress and rescued by antidepressant.The diversity and modulation of synaptic plasticity is likely to play important roles in both physiological learning and related pathological conditions.