Bradykinin prevents oxidative stress induced senescence of endothelial progenitor cells via B2 recep

来源 :第十二届中国介入心脏病学大会(CIT2014) | 被引量 : 0次 | 上传用户:xiaoxi0504
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Background Oxidative stress induced senescence of endothelial progenitor cells (EPCs) plays an important role in diabetes mellitus (DM).Effect of bradykinin (BK) protects against senescence of EPCs remains unknown.Methods Human umbilical veins endothelial progenitor cells (HUVEPCs) were separated into 6 groups: 300 μmol/L H2O2 treated group,300 μmol/L H2O2+10 nmol/L BK treated group,300 μmol/L H2O2+10 nmol/L BK+10 μmol/L LY294002 treated group,300 μmol/L H2O2+10 nmol/L BK+B2R siRNA treated group and control.
其他文献
Background Pulmonary arterial hypertension (PAH) is a serious and poor prognosis complication of systemic lupus erythematosus (SLE),early diagnosis and treatment is helpful to improve the prognosis.We
会议
Background Calcification is a common finding in coronary arteries and has long been known to occur as a part of the atherosclerotic process.The purpose of this study was to observe the frequency and d
会议
Background Generally the incidence of infection relate to cardiovascular intervention is low.However,stent-graft infection may result in life-threatening serious adverse outcomes to our patients after
会议
Background MTHFR 677C>T polymorphism is a genetic alteration in an enzyme involved in folate metabolism,but its effect on susceptibility to abdominal aortic aneurysm (AAA) is still uncertain.The aim o
会议
Background To provide evidence that rosuvastatin could improve insulin-resistance and inhibit atherogenesis by modulating insulin signaling,and whether this effect beyond its plasma cholesterol-loweri
会议
Background Essential hypertension (EH) is an etiological risk factor that poses a serious threat to human health.The aim of this study therefore was to investigate the correlation between the two SNPs
会议
Background We aim to assess if the relationship between short or long sleep duration and hypertension is present among adults from epidemiological evidence and to investigate the relationship quantita
会议
Background The quantitative associations between prehypertension or its separate blood pressure (BP) ranges and the risk of main cardiovascular outcomes,including stroke,coronary heart disease (CHD),m
会议
Background To discuss the affect of exosomes secreted by mesenchymal stem cells,which were treatmented by 5-aza or hypoxia,on the the ability of BM-MSCs to promote itself myocardial differentiation or
会议
Background Pediatric obesity has become a global public health problem.Data on the lifestyle behaviors,dietary habits,and familial factors of overweight and obese children and adolescents are limited.
会议