Antibodies against Non Small Lung Cancer Cells and their Role in Diagnosis and Immunotherapy of Lung

• 作 者: GiulioTarro;
• 机 构: Division of Infectious Diseases D Cotugno Hospital Italy
• 出 处: 2011第三届中国北京抗体大会
• 发表日期: 2011年期

　　TLP is a tumor-associated antigen and a 100 kDa protein overexpressed in lung tumors and other epithelial adenocarcinomas.It is immunogenic in humans as shown by serum antibodies.Since TLP is a fragment of a protein identified in extracts of human Non Small Cell Lung (NSCL) cancer and colorectal cancers (CRC), and its sequences stimulate cytotoxic immunoresponse in humans and animal models, it is possible to design potential active and passive immunotherapies for NSCL cancer and CRCs based on TLP epitopes and humanized antibodies.