【摘 要】
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Objective To investigate the impact of intensive statin therapy on periprocedual platelet parameters in older patients with non-ST elevated acute coronary syndrome (NSTE-ACS) undergoing percutaneous c
【机 构】
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12th Ward,Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing Instit
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Objective To investigate the impact of intensive statin therapy on periprocedual platelet parameters in older patients with non-ST elevated acute coronary syndrome (NSTE-ACS) undergoing percutaneous coronary interventions (PCI).Methods A total of 138 patients over 65 year old with unstable angina pectoris or non ST segment elevation myocardial infarction in Beijing Anzhen Hospital of capital medical university were included.They were divided into conventional therapy group (received 20 mg atorvastatin per day, n=70) and intensive treatment group (received 80 mg load dose of atorvastatin then 40 mg per day, n=68) before PCI of 12 hours.Blood platelet count (PLT), mean platelet volume (MPV), platelet distribution (PDW) and platelet-large cell ratio (P-LCR) were measured at baseline, platelet parameter were measured after PCI of 1 and 5 days, and the platelet aggregation rate induced arachidonic acid and adenosine diphosphate were measured.Results There were no significant differences on platelet parameter after admission and PCI of 1 and 5 days between two groups (P>0.05).Compared with base line, platelet counts of conventional therapy group after PCI of 1 day significant decrease [(210±60) G/L vs (206±62) G/L, P=0.02], MPV levels [(10.6 ±0.9) fL vs (10.8 ±0.9) fL,P=0.001], PDW levels [(12.5±1.9) % vs (12.8± 1.9) %,P=0.03], and P-LCR levels [(32±8) % vs (30± 8) %, P=0.001] were significant increased, there were significant differences.There were no different on platelet parameters in intensive treatment group after PCI of 1 day compared with baseline (P>0.05).MPV [(10.6± 1.0) fL 比 (10.8±1.0) fL, P=0.02] andP-LCR [(30±9) %比 (31±8) %, P=0.02] of intensive treatment group were decreased significantly on 5 day after PCI.Conclusion Atorvastatin may beneficially inhibit the increasing of MPV, PDW, P-LCR results from PCI.This effect of atorvastatin could play a role in decrease platelet activation and reduce cardiovascular risk for NSTE-ACS patients.
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