Neurometabolite characteristics in anterior cingulate cortex of Alzheimers disease with depressive s

• 作 者: Zhongwei Guo Xiaozheng Liu Hongtao Hou Yulin Cao Fuquan Wei Yougen Cheng Japeng Li Xingli Chen Wei Chen
• 机 构: ZhejiangMentalHealthCenter,Hangzhou,Zhejiang,ChinaCenterforCognitionandBrainDisorders,HangzhouNormal
• 出 处: 浙江省预防医学会精神卫生专业委员会成立大会暨学术交流会
• 发表日期: 2015年8期

BACKGROUND:Depression is a common comorbid condition in Alzheimers disease (AD), particularly in the early stages, and the prevalence of depression is higher among people with AD compared to older adults with normal cognition.Comorbidity with depression may increase the risk of cognitive decline, impair a patients function and quality of life.Therefore, understanding the mechanisms is important in order to increase the efficiency of early diagnostics and the selection of optimal treatment strategy for these conditions.Proton magnetic resonance spectroscopy (1H-MRS) is a noninvasive magnetic resonance imaging (MRI) method to measure brain metabolite concentrations, and has been used in clinical studies of major depressive disorder (MDD) and AD.