【摘 要】
：
The aim of the present study was to determine whether herpes simplex virus-1 (HSV-1) can be made prostate-specific and oncolytic by either co-infecting an a
【机 构】
：
Brain Research Center University of British Columbia Canada
【出 处】
：
BIT Life Sciences' 1st Annual World Cancer Congess-2008(
论文部分内容阅读
The aim of the present study was to determine whether herpes simplex virus-1 (HSV-1) can be made prostate-specific and oncolytic by either co-infecting an amplicon containing a probasin-derived promoter (ARR2PB) upstream of an essential HSV-1 gene icp4 to complement a HSV-1 helper virus with this gene deleted (icp4-) or by creating a recombinant virus with the ARR2PB promoter replacing the promoter of another essential HSV-1 gene icp27 (ARR2PB27).Two amplicon constructs, CMV-ICP4 and ARR2PB-ICP4,were packaged by a replication-deficient icp4-helper virus.While amplicon CMV-ICP4 complemented icp4-helper viruses to replicate in Vero cells, the ARR2PB-ICP4 was more specific for prostate cancer cells, causing virus replication and cell lysis in an androgen dependent fashion.Intra-tumoral injection of LNCaP human prostate cancer xenografts with either amplicon plus helper virus resulted in >75% reduction in tumor volume and serum PSA.Histological and Q-PCR analyses indicated that toxicity in non-tumor tissues was much lower with ARR2PB-ICP4 than with CMV-ICP4 amplicon/helper virus.
其他文献
中国樱桃硬枝扦插育苗法笔者于１９９１年～１９９３年，在本站苗圃进行中国樱桃硬枝扦插对比试验，生根成苗率达８０％以上。其方法如下：１．扦插时期。１０月上中旬，日平均地温１０～１５℃为宜。此期扦插，插穗不致因高温腐烂
Nischarin is a novel protein that binds to p21 activated kinase and alpha 5 integrin.Recently, we have demonstrated Nischarin regulates tumor cell migration
请下载后查看，本文暂不支持在线获取查看简介。
Please download to view, this article does not support online access to view profile.
1.南g之花(148X108cm)2.苏州虎丘(55 X 40cm)3.北国风光(148 X 99m)4.节日前夕(144X1091th)6.西双版纳(55 X 4肌4’6.向日葵(137X10311)7.秋虫鸣(113X827m)Mgt”if]IMlyweM、
One of the major impacts in oncology during last few years was the finding of lisp70 at the surface of cancer cells in association with tumor antigens.It wa
竹荪是我国的高档出口商品,其味道鲜美,营养丰富,有“菌中皇后”之誉,古为帝王佳肴,今为国宴名菜;且有多种药用价值,如:降低胆固醇防治高血压,消除腹脂防治肥胖症,含有抗癌
阿华虎年得子,分娩顺利,母子平安。听从医生的忠告,采取了母乳喂养。只见宝宝长得又白又胖,阿华自已也恢复得不错。谁料想,产后四个多月的一天,阿华忽觉味口不佳,频频作呕,
Focal Adhesion Kinase (FAK) is expressed and activated at higher levels in malignant cells than in normal cells.Previously we reported that FAK knockdown in
近年来,广州市通过联营、租赁、合作等多种方式,积极引进外资进行老港口改造和新港口建设,加强了广州港作为华南国际贸易主枢纽港的地位。 从1990年开始,广州市利用外资的港
铜版画本身具有丰富细腻的表现优势。灰色调的主体与大片空白对比,形成一种表现样式,通过黑白色调的丰富变化营造出一种神秘、清冷而又深远的意境,而这艺术追求的实现,则要