mTOR activation is known to suppress autophagy by phosphorylating ULK1 at S757 and deactivating its enzymatic activity.Here we report that feedback activation of the mTOR-PI3K pathway by two S6K1 inhi
Ochratoxin A(OTA),a worldwide mycotoxin found in food and feeds,is a potent nephrotoxin in animals and humans.Porcine circovirus-associated disease(PCVAD),including porcine dermatitis and nephropathy
Leflunomide is an immunosuppressive drug prescribed for treating rheumatoid arthritis(RA).Our recent study showed that A77 1726,the active metabolite of leflunomide,inhibits the activity of p70 S6 kin
[Background] A virulent pseudorabies virus(PRV)variant emerged in many porcine farms in China from 2011.Even though vaccines made of PRV Bartha K61 strain could provide protection,but poor protection
[Objective] This study aimed to investigate the potential of virus-like particles(VLPs)from rabbit hemorrhagic disease virus(RHDV)as a delivery system for foreign epitopes.
Use of adjuvant containing pathogen pattern recognition receptor agonists is one of the effective strategies to enhance the efficacy of licensed vaccines.In this study,we investigated the efficacy of
Zearalenone(ZEA)is a non-steroidal estrogenic mycotoxin produced by fungi belonging to the fusarium sp.using a polyketide pathway.ZEA causes reproductive disorders and testicular toxicity in animals.S