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目的回顾性研究老年系统性红斑狼疮(SLE)患者合并感染的危险因素。方法选取1995年1月-2009年12月间在四川大学华西医院确诊为SLE,起病年龄为50周岁以上的158例患者,收集性别、临床表现、疾病活动度、实验室检查指标、合并症以及并发症等进行单因素分析或多因素非条件logistic回归分析。结果所纳入的158例患者中,合并感染53例(占33.5%),采用单因素分析显示疾病活动性(P=0.001)、低蛋白血症(P=0.030)、糖尿病(P=0.003)、肺间质病变(P=0.000)与老年SLE患者感染发生有关。经logistic回归分析显示,疾病活动性(OR=7.533,P=0.000)、肺间质病变(OR=19.762,P=0.000)、糖尿病(OR=6.862,P=0.025)是老年SLE患者感染发生的危险因素。结论积极控制老年SLE的疾病活动度,减少危险因素的发生是控制老年SLE患者并发感染的有效手段。
Objective To retrospectively study the risk factors of combined infection in elderly patients with systemic lupus erythematosus (SLE). Methods A total of 158 patients with SLE diagnosed at West China Hospital of Sichuan University from January 1995 to December 2009 were enrolled in this study. Their gender, clinical manifestations, disease activity, laboratory tests, complications And complications such as univariate analysis or multivariate non-conditional logistic regression analysis. Results Of the 158 patients enrolled, 53 (33.5%) had co-infections and were confirmed by univariate analysis of disease activity (P = 0.001), hypoproteinemia (P = 0.030), diabetes (P = 0.003) Interstitial lung disease (P = 0.000) was associated with the development of SLE in elderly patients. Logistic regression analysis showed that the disease activity (OR = 7.533, P = 0.000), interstitial lung disease (OR = 19.762, P = 0.000) and diabetes (OR = 6.862, P = 0.025) Risk factors. Conclusions Active control of disease activity in elderly SLE and reduction of risk factors are effective measures to control concurrent SLE patients.