【摘 要】
：
含氮杂环化合物是很多重要的天然产物及药物分子的基本骨架,含氮杂环化合物的合成方法学一直是有机化学的热点研究课题.亚胺自由基的环化反应是合成氮杂环化合物的一种重要方
【机 构】
：
兰州大学功能有机分子化学国家重点实验室
论文部分内容阅读
含氮杂环化合物是很多重要的天然产物及药物分子的基本骨架,含氮杂环化合物的合成方法学一直是有机化学的热点研究课题.亚胺自由基的环化反应是合成氮杂环化合物的一种重要方法[1].我们课题组最近研究发现,过氧叔丁醇和四丁基碘化铵组成的氧化体系可以高效地将亚胺氧化为亚胺自由基.利用该氧化体系,我们对α-亚胺-N-芳基酰胺化合物的自由基环化反应做了深入的机理方面的探讨[2].在此工作基础上,我们发展了新的由次氯酸叔丁酯(t-BuOCl)、四丁基碘化铵(TBAI)和四丁基氯化铵(TBAC)组成的氧化体系,实现了从α-亚胺-N-芳基酰胺到喹喔啉酮的高产率转化(Scheme 1).该反应为喹喔啉酮类化合物的合成提供了新的简便方法.
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