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Objective: To prepare and investigate the physicochemical properties and antitumor activity of paclitaxel loaded cRGD-CMCh-PA micelles.Methods: (1) cRGD-CMCh-PA was synthesized and characterized by FT-IR and 1H-NMR.(2) PTX-CMCh-PA micelles were prepared and studied with the particle size distribution, zeta potential, morphology and release behavior in vitro.