【摘 要】
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The eleven human histone deacetylases (HDACs) are essential epigenetic regulators of gene transcription,functioning throughspatial-temporal recruitment of prote
【机 构】
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DepartmentofMolecularBiology,PrincetonUniversity,Princeton,U.S.A.
论文部分内容阅读
The eleven human histone deacetylases (HDACs) are essential epigenetic regulators of gene transcription,functioning throughspatial-temporal recruitment of protein complexes.HDAC dysfunction is critically linked to cancer,immune,infectious,and cardiacdisease.HDAC inhibitors are used in anti-cancer therapies,including cutaneous T-cell lymphomas.Yet,this inhibition is often markedby cytotoxicity due to the requirement of HDAC activity in numerous cellular processes.
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