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As the most common primary central nervous system tumor,glioma is characterized by high levels of mortality and migration.Unclear boundary with normal brain tissue results in poor treatment.The mammalian diaphanous-related formin 1(Diaph1)which belongs to formin-homology protein family,is a target of RhoA and involved in a number of actin-related biological processes,which abnormally expressed in pathological conditions in a number of tumors.