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Aims: To evaluate the therapeutic value of extensive lymphadenectomy and post operation chemotherapy in patients with node negative gastric cancer is controversial.Methods: Clinical data of 311 patients without lymph node metastasis were analyzed to evaluate the effect of extensive lymphadenectomy and post operation chemotherapy.The post operation survival rate of patients who underwent lymphadenectomy and post operation chemotherapy was compared with that of patients who underwent standard lymphadenectomy and without postoperation chemotherapy.Results: The survival rate was poor under the following scenarios: i)the patients were more than 65 years old, ii)tumor size is larger than 4cm, iii)tumor is located in the upper, iv) patients were in pT3 status.The survival rate of patients improved significantly by extensive lymphadenectomy only in pT3 status, but not improved in other status.Moreover, there were no significant difference in survival rate between patients with post operation chemotherapy and patients without post operation chemotherapy.Conclusions: Extensive lymphadenectomy prolonged the survival rate of the patients with pT3 node-negative gastric cancer.The patients with node-negative gastric cancer could not get benefit from post operation chemotherapy.