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Purpose: Histone deacetylases(HDAC)are regarded as important defining the epigenetic program during the lineage differentiation of stem cells.A better understanding of this epigenetic mechanism,that governs osteogenic differentiation of human adipose-derived stromal cells(hADSCs),would promote/improve bone tissue engineering research and provide new insights into the modulation of hADSC-based therapy.The aim of this study was to investigate the effect of a novel HDAC3-selective inhibitor(MI192)on hADSC proliferation and osteogenic differentiation in vitro.