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  5. DDB1/CUL4-associated Factor-13(DCAF13)Endows Zygotes the Genome Remodeling Capability by Triggering

DDB1/CUL4-associated Factor-13(DCAF13)Endows Zygotes the Genome Remodeling Capability by Triggering

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：wsl526
【摘 要】
：
Mammalian oocytes/zygotes are different from somatic cells in their ability to reprogram somatic cells into a totipotent state enabling animal cloning through somatic cell nuclear transfer(SCNT).SUV39
【作 者】
：
Heng-Yu Fan 
【机 构】
：
Life Sciences Institute,Zhejiang University,Hangzhou,China
【出 处】
：
2016年国际生理学学术大会
【发表日期】
：
2016年6期
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　　Mammalian oocytes/zygotes are different from somatic cells in their ability to reprogram somatic cells into a totipotent state enabling animal cloning through somatic cell nuclear transfer(SCNT).SUV39H1/2-mediated histone H3 lysine-9 trimethylation(H3K9me3)of donor cell genome is a major barrier for efficient reprogramming by SCNT.However,it remained unclear how the SUV39H1/2 activities were removed in early embryos derived from normal fertilization or SCNT.
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