【摘 要】
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The cytochrome P450 superfamily (CYP) is a group of monooxygenases which perform many necessary functions in human body.As the major drug-metabolizing enzym
【机 构】
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State Key Lab.Of Microbial Metabolism and College of Life Science and Biotechnology, Shanghai Jiaoto
论文部分内容阅读
The cytochrome P450 superfamily (CYP) is a group of monooxygenases which perform many necessary functions in human body.As the major drug-metabolizing enzymes, CYP enzymes are responsible for the metabolism of a large number of drugs.In addition, CYP is subject to genetic polymorphism resulting in the inter-individuals difference in drug-metabolizing ability.Thus, the main focus of recent CYP researches includes the CYP-mediated drug metabolism, the substrate specificity of different CYP isoenzymes, the influences of different genetic polymorphisms on function of CYP enzymes and the possible mechanism for changing enzymatic activity of CYP due to mutation of amino acid.
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