• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Functional analysis of TNNI3K gene and the new drug development for suppressing risk of cardiogenic

Functional analysis of TNNI3K gene and the new drug development for suppressing risk of cardiogenic

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：hnldlxz
【摘 要】
：
TNNI3K is a MAP kinase specifically and continuously expressed in cardiac muscle and interacted with cardiac troponin Ⅰ (TNNI3, or cTnI).The aim of this study is to investigate role of TNNI3K interact
【作 者】
：
Zhong-Fang LAI Hoichi YORINAKA Yu-Zhen CHEN 
【机 构】
：
Department of Pharmacology & Molecular Therapeutics,Graduate School of Medical Sciences Kumamoto Uni
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
TNNI3K is a MAP kinase specifically and continuously expressed in cardiac muscle and interacted with cardiac troponin Ⅰ (TNNI3, or cTnI).The aim of this study is to investigate role of TNNI3K interacting with cTnI in modification of the physiological function of cardiomyocytes and suppression of some pathological injuries and to explain the new molecular mechanism for TNNI3K-mutant in the ischemic coronary heart diseases, and hope to develop some new therapeutic strategies.
其他文献
Chronic restraint stress promotes learning and memory Impairments due to enhance oxidative stress in
Aim: Chronic stress is implicated in many types of neurodegenerative diseases such as Alzheimers disease (AD).The present study investigated the effects of chronic restraint stress (CRS) on learning a
会议
chronic restraint stressAlzheimer's diseasereactive oxygen speciesNADPH
Targeting cPLA2 inhibition to reduce lysophosphatidylcholine (LPC) production induced by Cdk5/p25: A
Aim: The deregulation of cyclin-dependent kinase 5 (Cdk5) by p25 and neuroinflammation has been linked to the pathogenesis in a number of neurodegenerative diseases such as Alzheimers disease (AD), AL
会议
neuroinflammationCdk5/p25cytosolic phospholipase A2lysophosphatidylcholineas
Effects of AGAP, a analgesic-antitumor peptide, on voltage-gated ion channels in acutely isolated ra
Aim: Previous studies showed that analgesic-antitumor peptide (AGAP) has analgesic activities tested.In this study, the effects of AGAP on ion channels including VGSC, VGCC and VGPC were investigated
会议
AGAPVGSCNav1.8TTX-R sodium channelsVGCC
ER-α36, a novel variant of ER-α, was involved in the progression and acquired tamoxifen-resistance i
Aim: It is established that glioma, the most common form of primary brain tumor, possess the characteristic of high incidence rate and difficult therapy.Recent studies indicated that Tamoxifen (TAM) c
会议
ER-α36tamoxifengliomaacquired resistance
The cell models of microglia activation by different stimulators
Aim: Recently, research of the contribution of activated microglia in Alzheimers disease (AD) has become a new research hotspot.To further explore the role of reactive microglia in AD, we compare the
会议
microgliatumor necrosis factor-αβ-amyloidAlzheimer's disease
Aldosterone metabolism and nonsteroidal anti-inflammatory drugs (NSAIDs): A link to increased cardio
Considerable evidence exists that use of non-selective (eg, diclofenac) and cyclooxygenase (COX)-2 selective (eg, celecoxib) NSAIDs is associated with increased cardiovascular (CV) risk.Although the m
会议
aldosterone metabolismNSAIDscardiovascular risk
Inhibition of angiogenesis by HDAG inhibitor ZYJ-34c in vitro
Aim: A tetrahydroisoquinoline-based hydroxamic acid derivative (ZYJ-34c) as histone deacetylase inhibitor, inhibited the growth of human breast carcinoma (MDA-MB-231) xenograft, a mouse hepatoma-22 (H
会议
histone deacetylase inhibitorZYJ-34canti-angiogenesis
Effect of protein tyrosine phosphatase inhibitor in the regulation of atrial ANP release
Aim: It was reported that phosphoprotein is involved in the regulation of ANP release.In this study, the effect of potassium bisperoxo(1,10-phenanthroline) oxovanadate [bpv(phen)], a protein tyrosine
会议
atrial natriuretic peptideprotein kinase Cprotein tyrosine phosphatase
Protective effect of baicalein against myocardial ischemia-reperfusion injury in rats
Aim: To investigate protective effect of baicalein on myocardial ischemia-repeffusion injury in rats, Methods: The myocardial ischemia-reperfusion injury model was established in rats by ligating left
会议
baicaleinmyocardial ischemiareperfusion injury
Role of perivascular adipose tissue in regulation of vascular tone
Ample evidence indicates that the perivascular adipose tissue (PVAT) plays important roles in regulating vascular tone via releasing vasorelaxing and constricting mediators.Among them, a spontaneously
会议