The cell models of microglia activation by different stimulators

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：JK0803_wantao

【摘要】

：

Aim: Recently, research of the contribution of activated microglia in Alzheimers disease (AD) has become a new research hotspot.To further explore the role of reactive microglia in AD, we compare the

【作者】

：

Gang LIU Zeng-yao HU Yan HUANG Wen-xia ZHOU Yong-xiang ZHANG

【机构】

：

Institute of Pharmacology and Toxicology, Beijing 100850, China

【出处】

：

The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

：

2013年4期

【关键词】

：

microglia tumor necrosis factor-α β-amyloid Alzheimer's disease

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Aim: Recently, research of the contribution of activated microglia in Alzheimers disease (AD) has become a new research hotspot.To further explore the role of reactive microglia in AD, we compare the effects of the stimulators (aggregated and nnaggregated Aβ25-35, LPS, IFN-γ) on microglial cell line BV-2.Methods: Aβ25-35 peptides were resuspended in sterile dH2O (final concerntration, 1 mmol/L) and incubated at 37℃ for 1 week to prepare the aggregated Aβ.

其他文献

The effects of flupirtine on acute stress-induced impairment of hippocampal long-term potentiation a

Aim: Learning and memory are greatly modified by stress and hippocampal synaptic plasticity such as long-term potentiation (LTP), a putative hippocampal memory mechanism are impaired by acute stress.T

会议

Kv7/M channelacute stressflupirtinelong-term potentiation (LTP)

Icariin decreases APP, Aβ levels and stimulats neurogenesis in the brain of Tg2576 mice

Aim: Icariin (ICA) is a major fraction of flavonoids derived from the Chinese medical herb Epimedium brevicornum Maxim.Our previous studies have shown that ICA can protect neuron from different memory

会议

IcariinAβAPPneurogenesisTg2576 mice

Neuroprotective effects of oxysophocarpine on neonatal rat primary cultured hippocampal neurons inju

Aim: In this study we investigated the protective effects of oxysophocarpine (OSC) on neonatal rat primary cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion (OGD/RP).M

会议

oxysophocarpine (OSC)hippocampal neuronsoxygen-glucose deprivation and reperfu

Regulation of neuroinflammation by liver X receptors: differential mechanisms through SHP

We have previously reported that endogenous (oxysterols) as well as synthetic (GW3965, TO0901317) ligands of Liver X Receptor (LXR) efficiently suppressed STAT1 inflammatory signals in IFN-gamma-stimu

会议

liver X receptorsmall heterodimer partnerSTAT1SUMOylation

Beneficial effects of tetrahydroxy-stilbene glucoside on multiple targets of Alzheimer's diseas

Aim: Alzheimers disease (AD) is a multifactorial complex disease.The failure of recent development of AD therapeutic agents in clinical trials is partly due to their single-target effect.The purpose o

会议

Alzheimer's diseasetetrahydroxy-stilbene glucosidemultitarget therapy

Effects of potassium channel on neuronal apoptosis induced by oxygen-glucose deprivation with or wit

Aim: It was generally believed that excessive potassium efflux was one of the primary causes of neuronal injury after cerebral ischemia, so inhibition of the excessive potassium channels might play a

会议

potassium channelcerebral ischemianeuronastrocyteapoptosis

Chronic restraint stress promotes learning and memory Impairments due to enhance oxidative stress in

Aim: Chronic stress is implicated in many types of neurodegenerative diseases such as Alzheimers disease (AD).The present study investigated the effects of chronic restraint stress (CRS) on learning a

会议

chronic restraint stressAlzheimer's diseasereactive oxygen speciesNADPH

Targeting cPLA2 inhibition to reduce lysophosphatidylcholine (LPC) production induced by Cdk5/p25: A

Aim: The deregulation of cyclin-dependent kinase 5 (Cdk5) by p25 and neuroinflammation has been linked to the pathogenesis in a number of neurodegenerative diseases such as Alzheimers disease (AD), AL

会议

neuroinflammationCdk5/p25cytosolic phospholipase A2lysophosphatidylcholineas

Effects of AGAP, a analgesic-antitumor peptide, on voltage-gated ion channels in acutely isolated ra

Aim: Previous studies showed that analgesic-antitumor peptide (AGAP) has analgesic activities tested.In this study, the effects of AGAP on ion channels including VGSC, VGCC and VGPC were investigated

会议

AGAPVGSCNav1.8TTX-R sodium channelsVGCC

ER-α36, a novel variant of ER-α, was involved in the progression and acquired tamoxifen-resistance i

Aim: It is established that glioma, the most common form of primary brain tumor, possess the characteristic of high incidence rate and difficult therapy.Recent studies indicated that Tamoxifen (TAM) c

会议

ER-α36tamoxifengliomaacquired resistance

The cell models of microglia activation by different stimulators

其他学术论文