Viral protein-repressed microRNA-148a controls tumor growth and metastasis through HPIP-mediated mTO

• 作 者: 徐小洁
• 机 构: 军事医学科学院
• 出 处: 北京细胞生物学会首届青年学者论坛
• 发表日期: 2013年9期

MicroRNAs (miRNAs) have been shown to be dysregulated in virus-related cancers; however, miRNA regulation of virus-related cancer development and progression remains poorly understood.Here, we report that miR-148a is repressed by hepatitis B virus (HBV) X protein (HBx) to promote cancer growth and metastasis in a mouse model of hepatocellular carcinoma (HCC).Hematopoietic pre-B cell leukemia transcription factor-interacting protein (HPIP) is an important regulator of cancer cell growth.