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Adiponectin is an abundant,oligomeric protein secreted from adipose tissue,which exhibits a variety of remarkable salutary responses that affect insulin resistance and vascular inflammation.In obesity and insulinresistant states, adiponectin levels are reduced and loss of its protective effects might contribute to the excess cardiovascular risk observed in these conditions.Adiponectin ameliorates the progression of macrovascular disease in rodent models,consistent with its correlation with improved vascular outcomes in epidemiological studies.