【摘 要】
：
Limiting unnecessary ventricular pacing (VP) in patients (pts) who receive a dual-chamber (DDD) pacemaker (PM)appears desirable.Programming long AV delays has serious limitations in that respect: long
【机 构】
：
S Montreal Heart Institute University of Montreal Canada
【出 处】
：
BITs 2rd Annual World Cancer Congress of Cardiology-2010(201
论文部分内容阅读
Limiting unnecessary ventricular pacing (VP) in patients (pts) who receive a dual-chamber (DDD) pacemaker (PM)appears desirable.Programming long AV delays has serious limitations in that respect: long PR intervals may be suboptimal to preserve AV synchrony, and often times % of VP >10% are observed despite all the efforts to minimize VP.The SafeRTM mode by Sorin is one of the available algorithms that aim to minimize unnecessary VP while decreasing the associated risk of AAI pacing.Methods: CAN-SAVE is a Canadian multi-center randomized study that compares the efficacy the SafeRTM mode with DDD pacing with a long AV delay in a large population of pts without permanent high degree AV Block (AVB).We report the results of the data at the pre-specified interim analysis.375 pts were randomized: 63% males, mean age=71±10 years, LVEF=60±10%, LAVol=23±10mL/m2.Pacing indications were Sinus Node dysfunction (SND) (47%), AV block (24%), SND + AV block (14%) and other (15%).After a mean follow-up of 2 years, compliance with pacing mode is >95% for both groups ofpts.The SafeR algorithm effectively decreases % of VP to 5.6±14.5% compared to 25.7±34.3% in the control group (P<0.0001) with 68% of the pts with <1% VP compared to 36% (P<0.0001).However, this was not associated with a decrease in AF burden (1.9±7.9% in SafeR group vs.2.0±8.0% in control, P=NS).Conclusions: The SafeR algorithm from Sorin is safe and effective to prevent unnecessary ventricular pacing.At short term, this has no impact on AF occurrence but longer follow-up is scheduled to specifically address this issue.
其他文献
A prerequisite for a normal cardiac function is a proper generation and propagation of electrical impulses.A pivotal element of the impulse propagation is the depolarizing sodium current, responsible
The "late sodium current" (late INa) is a sustained component of the fast Na+ current of cardiac myocytes.It is due to the lack of inactivation or to late reopening of the voltage-gated Na+ channels.L
In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function.Altogether, over 50 inherited ion channel-related disorders are c
Human cholestcryl ester transfer protein (CETP), a hydrophobic glycoprotein (476 amino acids, ~74 kDa), mediates the transfer of cholesteryl ester (CE) from high-density lipoproteins (HDL) to apo-B co
Cyclooxygenase-2 (COX-2) inhibitor use for coronary artery bypass graft (CABG) postoperative pain has been linked to adverse cardiovascular outcomes.An FDA black-box warningon the use of all NSAIDs pe
Cardiac arrhythmias are a source of significant morbidity and mortality worldwide.Nowadays, their treatment is still based on drugs with limited efficacy and safety profile, mainly due to our lack of
It is well known that antagonists of mineralocorticoid receptor (MR), a classic steroid hormone receptor, are cardioprotective and anti-inflammatory.These effects can be independent of hyperaldosteron
Any incident with potential deleterious consequences occurring while treating a patient with a medical device concerned medical device vigilance.In Europe, as well as in other part of the world, direc
The World Survey of Cardiac Pacing and Cardioverter Defibrillators is compiled every 4 years with the most recent results being for the calendar year 2005 and demonstrating a significant worldwide inc
Pacing at the right ventricular apex (RVA) is associated with a higher risk of cardiac failure.Unfortunately little is known about alternative pacing or defibrillation sites.We are aiming alternative