【摘 要】
：
The study of Coxsackie virus type A 16 (CA16), a major causative agent of hand, foot and mouth disease (HFMD), has suggested that two types of virions could be harvested from cell cultures: a real (R)
【机 构】
：
Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Institute of
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
The study of Coxsackie virus type A 16 (CA16), a major causative agent of hand, foot and mouth disease (HFMD), has suggested that two types of virions could be harvested from cell cultures: a real (R) virion fraction containing complete viral particles and a pseudo (P) virion fraction containing defective particles.To investigate the biological characteristics of the virion fractions, especially their immunogenicity, this study examined the differences in the structure, pathogenicity and immunogenicity of the two virions.
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