【摘 要】
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T cell antigen receptor (TCR) ligation induces the formation of TCR proximal LAT signalosome complexes including PLC-γ1, GRB2, Themis and SLP76.The formation and regulation of this signalosome is esse
【机 构】
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Institute of Immunology, Program in Molecular and Cellular Biology,Zhejiang University School of Med
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
T cell antigen receptor (TCR) ligation induces the formation of TCR proximal LAT signalosome complexes including PLC-γ1, GRB2, Themis and SLP76.The formation and regulation of this signalosome is essential for mediating subsequent signal transduction, including mitogen-activated protein kinases, protein kinase C pathways and calcium flux.Tespa1, a newly-identified adaptor protein, is also recruited to the LAT signalosome and interacts with PLC--γ1 and GRB2.
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