NEUROTOXICITY相关论文
卡西酮类策划药的结构和药效与苯丙胺类兴奋剂相似，多通过对已管制毒品进行细微化学修饰或全新设计、筛选获得，使人体产生类似或更强......
全身麻醉药对发育期大脑具有潜在神经毒性作用。组蛋白去乙酰化酶抑制剂（histone deacetylase inhibitors, HDACIs）可通过提高细胞内......
目的探讨miR-133b在甲基苯丙胺(methamphetamine，MA)依赖大鼠脑内表达情况及其对神经元毒性损伤的调控作用。方法通过腹腔内连续注......
机体在环境中的过量氟暴露可导致多种健康危害，其中神经系统损害尤为严重。已经有大量实验及临床资料证实，摄入环境中过量的氟会引起......
目的探讨在异氟烷麻醉总时间一致的前提下，不同麻醉时间间隔对发育期大鼠急性脑损伤后认知行为的影响。方法选用生后7 d的SD大鼠，按......
全身麻醉是通过全身麻醉药作用于中枢神经系统（CNS），尽管最初人们认为全身麻醉药对CNS的影响是可逆的，并不会对大脑造成长期不良影响，但......
氨甲喋呤(MTX),其结构与叶酸及二氢叶酸还原酶抑制剂类似。常用于治疗风湿、肿瘤、炎症和皮肤疾病等。近年来,甲氨蝶呤是治疗儿童......
Protective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminer
The over-expression of α-synuclein is a major factor in the death of dopaminergic neurons in a methamphetamine-induced ......
Objective Antimony (Sb) has recently been identified as a novel nerve poison, although the cellular and molecular mechan......
Neural stem cell-based in vitro bioassay for the assessment of neurotoxic potential of water samples
Intensive agriculture activities,industrialization and growing numbers of wastewater treat-ment plants along river banks......
目的:通过短时间多次给药建立神经毒性模型,在不同时间点采用多种行为学观察装置,观察大鼠的行为反应,探讨MDMA神经毒性对大鼠焦虑......
Objective: In order to understand the neurotoxic mechanism of paclitaxel, the motility and apoptosis of the animal model......
目的 观察葡萄糖酸钙对草酸铂(L-OHP)引起的神经毒性的预防作用.方法 59例患者随机分为两组,研究组为葡萄糖酸钙+化疗(改良FOLFOX4......
Induction of chemotaxis to sodium chloride and diacetyl and thermotaxis defects by microcystin-LR ex
Apart from the liver disruption, embryotoxicity and genotoxicity, microcystin (MC)-LR also could cause neurotoxicity. Ne......
Identification of differentially expressed genes response to TCDD in rat brain after long-term low-d
Several cohort studies have reported that dioxin and dioxin-like polychlorinated biphenyls might impair the nervous syst......
Effects of Yizhi Capsule (益智胶囊) on Learning and Memory Disorder and β-amyloid Peptide Induced Neurot
Objective: To explore the effects of Yizhi Capsule (益智胶囊, YZC) on leing and memory disorder and β-amyloid peptide i......
目的：评价不同浓度七氟醚对大鼠原代皮质神经元的毒性作用。方法出生24 h 内的 SD 大鼠48只,体外培养大鼠皮质神经元并接种于6孔板(......
Aluminium-induced acute neurotoxicity in rats:Treatment with aqueous extract of Arthrophytum (Hammad
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Allantoin attenuates deficits of behavioural and motor nerve conduction in an animal model of cispla
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Objective: The aim of this study was to observe the efficacy of air wave pressure therapeutic equipment in prevention of......
Appropriate selection and measurement of lead biomarkers of exposure are critically important for health care management......
Effect of HIV-1 Tat on Secretion of TNF-α and IL-1β by U87 Cells in AIDS Patients with or without AI
Objective To explore the role of HIV-1 tat gene variations in AIDS dementia complex(ADC) pathogenesis.Methods HIV-1 tat ......
Objective To investigate acrylamide(ACR)-induced subacute neurotoxic effects on the central nervous system(CNS) at the s......
当前,大量临床及基础实验研究结果证实局麻药具有周围神经毒性损伤作用.然而,具体的损伤机制仍未明确.故临床上尚无有效措施以防治......
Disrupted-In-Schizophrenia 1 is a susceptibility gene for schizophrenia and other psychiatric disorders.Developmental le......
从细胞培养、啮齿类动物和非人类灵长类动物的实验研究中得到越来越多的证据：临床常用全麻药物对各期脑神经细胞产生毒性作用,损伤......
Objective To investigate the biochemical changes in rat brain and liver following acute exposure to a lethal dose of cya......
Effects of Yizhi Capsule (益智胶囊) on Learning and Memory Disorder and β-amyloid Peptide Induced Neurot
Objective: To explore the effects of Yizhi Capsule (益智胶囊, YZC) on learning and memory disorder and β-amyloid peptid......
目的 比较β淀粉样肽(AB)25-35和31-35对培养大鼠皮质神经元的毒性作用及其途径的差异,以进一步证明Aβ31-35是诱发神经细胞毒作用......
目的评价钙镁制剂和谷胱甘肽（GSH）对奥沙利铂（OXL）引起的神经毒性的预防作用。方法采用随机、双盲、安慰剂对照的方法，将接受FOLFOX4方......
胆红素脑病是新生儿期严重的高胆红素血症所致的神经功能障碍综合征,影响儿童神经系统的正常生长发育.随着对该病诊疗技术的发展,......
钴是参与维生素B12合成和许多生命活动中必不可少的微量元素，然而一旦机体细胞内的钴离子含量因职业暴露或因饮食摄取钴过量或因钴......
目的研究锰暴露不同时长对神经元细胞突触囊泡及其相关蛋白的影响。方法将体外培养的神经元,分别用100μM锰处理0、6、12、18、24 ......
目的 探讨朱砂和雄黄在安宫牛黄丸(AGNH)配方中对脂多糖(LPS)介导的神经损伤的保护作用及机制.方法 制备大鼠中脑原代神经元-神经......
高同型半胱氨酸血症(HHcy)是由同型半胱氨酸(Hcy)代谢异常引起的.HHcy既是心脑血管疾病的独立危险因素,也与多种神经退行性疾病和......
Effect of HIV-1 Tat on Secretion of TNF-α and IL-1β by U87 Cells in AIDS Patients with or without AI
ObjectiveToexplore the role of HIV-1 tat gene variations in AIDSdementia complex(ADC) pathogenesis. MethodsHIV-1tat gen......
Taurine and vitamin C influence 8-nitroguanine brain expression following sub-chronic arsenic exposu
BACKGROUND: Arsenic-induced overproduction of reactive nitrogen species results in damage to biomacromolecules in tissue......
过量锰暴露可能会损害中枢神经系统,产生不可逆转的神经毒性,导致严重的神经退行性疾病。锰的神经毒性机制可能与转运稳态失调、氧......
