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目的:研究高脂血症对胶原代谢的影响,以及调脂药物对胶原代谢的作用。方法:选择单纯脂代谢异常的患者67例,分别按胆固醇、三酰甘油和二者均升高分为3组,其中,高胆固醇血症组(高TC组)20例,每晚口服氟伐他汀40mg;高三酰甘油血症组(高TG组)20例,每日早空腹口服微粒化非诺贝特200mg;混合型高脂血症组(高TC、TG组)27例,联合应用氟伐他汀和微粒化非诺贝特,用法同前。分别于治疗前、治疗4,8周后测定Ⅲ型前胶原(PC-Ⅲ)浓度,治疗过程中监测药物不良反应。同时选年龄、性别相匹配的健康人20例作为正常对照组(正常组),入选时仅采空腹静脉血1次,观察指标同治疗组。结果:治疗前高TC、TG组、高TC组、高TG组与正常组比较,PC-Ⅲ浓度明显增加;血脂异常组各组之间比较,高TC、TG组上指标明显高于高TC组、高TG组;治疗组4,8周与治疗前血脂指标明显降低,PC-Ⅲ浓度均降低,且治疗8周均低于治疗4周。结论:血脂升高可以诱导胶原合成增加,调脂药物不仅能有效地降低血脂,而且能够抑制胶原合成。
Objective: To study the effect of hyperlipidemia on collagen metabolism and the effect of lipid-lowering drugs on collagen metabolism. Methods: Sixty-seven patients with dyslipidemia were divided into three groups according to cholesterol, triacylglycerol, and both. Among them, 20 were hypercholesterolemia group (high TC group) 40 mg of statins, 20 mg of hypertriglyceridemia group (high TG group) and 200 mg of fenofibrate (DB) as fasting morning fasting oral solution respectively. Twenty-seven patients with mixed hyperlipidemia (high TC, TG group) Statin and micronized fenofibrate, usage the same as before. The concentrations of procollagen type Ⅲ (PC-Ⅲ) were measured before treatment and after 4 and 8 weeks of treatment, respectively. Adverse reactions were monitored during the treatment. At the same time selected 20 healthy subjects of the same age and gender as the normal control group (normal group), selected only fasting venous blood 1 time, the observed indicators with the treatment group. Results: Compared with the normal control group, the concentration of PC-Ⅲ increased significantly in high TC, TG group, high TC group and high TG group before treatment. The indexes in high TC and TG group were significantly higher than those in high TC group Group and high TG group. At 4, 8 weeks after treatment, the level of PC-Ⅲ in the treatment group was significantly lower than that before treatment, and the level of PC-Ⅲ was decreased. Conclusion: Hyperlipidemia can induce the increase of collagen synthesis. Lipid-lowering drugs can not only effectively reduce blood lipid, but also inhibit collagen synthesis.