Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis

• 作 者: Martina Galatola Erasmo Miele
• 机 构: DepartmentofMolecularMedicineandMedicalBiotechnologyandCEINGEBiotecnologieAvanzate,DepartmentofTrans
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2013年46期
• 关键词: Inflammatory bowel disease ULCERATIVE colitis Interleukin 10 RECEPTORS TUMOUR ne
• 基金项目: Supported by A grant from Ministero Salute-Ricerca Oncologica-RECAM-2006-353005,PRIN 2007-prot.2007EN8F7T-004,Conven-zione CEINGE-Regione Campania.POR Campania FSE 2007-2013,Project CREME,PRIN 2010-20

AIM:To investigated the molecular cause of very early-onset ulcerative colitis(UC)in an 18-mo-old affected child.METHODS:We analysed the interleukin-10(IL10)receptor genes at the DNA and RNA level in the proband and his relatives.Beta catenin and tumor ne