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目的研究胃癌组织中P27kip1蛋白的表达及其与胃癌临床生物学行为的关系。方法采用免疫组织化学方法(SP法)检测胃癌组织和正常胃粘膜中P27kip1蛋白的表达。结果P27kip1蛋白阳性表达率在胃癌中(38%)显著低于正常胃粘膜(100%)(P<0.01);P27kip1蛋白表达与胃癌患者性别、年龄、肿瘤发生部位、大小及大体分型均无关(P>0.05)。P27kip1蛋白表达与胃癌分化程度、浸润深度、淋巴结转移、PTNM分期及术后5年生存率相关(P<0.05或P<0.01)。结论P27kip1蛋白的异常表达参与了胃癌的发生、发展。
Objective To investigate the expression of P27kip1 in gastric carcinoma and its relationship with the clinical biological behavior of gastric cancer. Methods The expression of P27kip1 in gastric cancer tissues and normal gastric mucosa was detected by immunohistochemistry (SP method). Results The positive rate of P27kip1 protein in gastric cancer was significantly lower than that in normal gastric mucosa (38%) (P <0.01). The expression of P27kip1 protein was not associated with gender, age, tumor location, size and gross type of gastric cancer (P> 0.05). P27kip1 protein expression was correlated with the degree of differentiation, depth of invasion, lymph node metastasis, PTNM stage and postoperative 5-year survival rate (P <0.05 or P <0.01). Conclusion The abnormal expression of P27kip1 protein is involved in the occurrence and development of gastric cancer.