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近年来国内外所报道的胺碘酮引起的心脏外不良反应中,以肺毒性最为严重,已有数例报道。病例均经病理组织学证实为肺间质或肺泡纤维化及局限性肺炎。肺损伤多在用药后数月内发生,也有的长达28个月。常见的临床表现为呼吸困难,咳嗽,发热。弥散功能异常,白细胞增多等。x线检查提示有弥漫性双肺间质改变,片状或弥漫性肺泡浸润。组织学表现为肺泡中泡沫细胞聚集,Ⅱ型肺泡上皮细胞增生,肺泡间隔增厚。电镜观察在肿胀的
In recent years, reports of amiodarone at home and abroad caused by extra-cardiac adverse reactions, the most serious pulmonary toxicity, has been reported in several cases. All cases were confirmed by histopathology as pulmonary interstitial or alveolar fibrosis and localized pneumonia. Lung damage occurred more than a few months after treatment, and some up to 28 months. Common clinical manifestations of dyspnea, cough, fever. Diffusion dysfunction, leukocytosis and so on. X-ray examination prompted diffuse interstitial lung changes, flaky or diffuse alveolar infiltration. Histological findings of alveolar foam cells in the accumulation of type II alveolar epithelial cell hyperplasia, alveolar septal thickening. Electron microscopy was observed in the swollen