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青霉素是一类对G~-菌具有强大杀菌作用的抗生素,目前第3代产品也已广泛用于临床。但在应用中仍存在一些问题,本文就其几个特殊问题,结合近年文献综述如下:1 青霉素过敏问题 1.1新生儿青霉素过敏 新生儿首次应用青霉素是否需做皮试,国内意见不一。不少医院对出生28d内的初生儿免做皮试,亦有持相反意见。晚近由于胚胎免疫学的进展,使过去许多困惑的问题有了满意的解释。认为胎儿在母体内第11周即开始合成IgE,但数量甚微,母体的IgE不能通过胎盘传给胎儿,故初生儿血中的IgE水平仅为成人的1％～5％,1～5个月时约为成人的25％。如此低水平,一
Penicillin is a class of G ~ - bacteria have a strong antibacterial effect of antibiotics, the current third generation products have also been widely used in clinical. However, there are still some problems in the application of this article on several special issues, combined with the literature in recent years are summarized as follows: 1 penicillin allergy problems 1.1 neonatal penicillin allergy neonatal first need to do skin test, domestic disagreement. Many hospitals do not do skin tests on newborns within 28 days of birth, and they also hold the opposite opinion. Recently, due to the progress of embryo immunology, many problems of the past have been satisfactorily explained. It is thought that the fetus begins to synthesize IgE in the 11th week of the mother’s body, but the quantity is very small. The mother’s IgE can not be transmitted to the fetus through the placenta. Therefore, the IgE level in the firstborn blood is only 1% -5%, 1 ~ 5 About 25% of adults are on month. Such a low level, one