Enantioselective chlorination of β-keto esters and amides catalyzed by chiral copper(Ⅱ) complexes of

• 作 者: Sheng-Jian Jia Da-Ming Du
• 机 构: School of Chemical Engineering and Environment,Beijing Institute of Technology,
• 出 处: Chinese Chemical Letters
• 发表日期: 2014年11期
• 关键词: esters complexes chiral catalyzed chlorinated asymmetric substituent moiety equi

Enantioselective chlorination of b-keto esters and amides catalyzed by squaramide-linked bisoxazoline ligand–Cu(OAc)2complexes was investigated. The corresponding chlorinated products were obtained in excellent yields with moderate enantioselectivities. The effect of solvent, temperature, Lewis acid, and ligand structure on the reaction is discussed. This was the first investigation of catalytic asymmetric achlorination of b-keto amides. This study has highlighted that a simple chiral squaramide–oxazoline with cheap Cu(OAc)2 H2 O complexes can catalyze this chlorination.

The corresponding chlorinated products were obtained in excellent yields with moderate enantioselectivities. The effect of solvent, temperature, Lewis acid, and ligand This was the first investigation of catalytic asymmetric achlorination of b-keto amides. This study has highlighted that a simple chiral squaramide-oxazoline with cheap Cu (OAc) 2 H2 O complexes can catalyze this chlorination.