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目的睡眠呼吸暂停综合征与冠心病关系密切,但国内尚缺乏有关的流行病学资料,本研究旨在了解国人冠心病(coronary heart disease,CAD)合并睡眠呼吸暂停综合征(sleep apnea syn- drome,SAS)的发生率及其相关关系。方法对2004年10月至2005年3月以胸痛待查或冠心病收入我巾心拟行冠状动脉造影的所有221例患者进行睡眠呼吸监测,及抽血化验血脂、尿酸、C-反应蛋白等,对其结果进行分析。结果共204例患者加入研究,冠状动脉造影确诊CAD154例,其中单支病变38例,双支病变47例,三支病变54例,左主干病变15例;冠状动脉造影确诊CAD的患者合并SAS 86例,发生率为55.8%;非CAD组50例,合并SAS 22例,发生率为44.0%。CAD组SAS发生率明显高于非CAD组(P<0.05)。Logistic回归分析显示校正年龄、吸烟、高血压等因素后,睡眠呼吸暂停指数(AHI)≥20的患者合并CAD的危险是AHI<20患若的7.7倍(P=0.017)。结论CAD合并SAS的发生率高,SAS是CAD可能的危险因素,对CAD患者应进行睡眠呼吸监测,及早诊断将有利于冠心病的治疗。
Objectives Sleep apnea syndrome is closely related to coronary heart disease, but epidemiological data are still lacking in China. This study aimed to understand the relationship between sleep apnea syn- drome (CAD) and sleep apnea syn- drome , SAS) incidence and its relationship. Methods From October 2004 to March 2005, 221 patients with chest pain or coronary heart disease who underwent coronary angiography were enrolled in the study. Their blood lipids, uric acid and C-reactive protein , Analyze its result. Results A total of 204 patients were enrolled in the study. Coronary angiography confirmed CAD154 cases, including 38 cases of single vessel disease, 47 cases of double vessel disease, 54 cases of three vessel diseases and 15 cases of left main vessel disease. Patients with CAD confirmed by coronary angiography and SAS 86 Cases, the incidence was 55.8%; non-CAD group of 50 patients with SAS in 22 cases, the incidence was 44.0%. The incidence of SAS in CAD group was significantly higher than that in non-CAD group (P <0.05). Logistic regression analysis showed that the risk of CAD in patients with sleep apnea index (AHI) ≥20 was 7.7-fold (P = 0.017) greater than those with AHI <20 after adjustment for age, smoking, hypertension and other factors. Conclusions The incidence of CAD combined with SAS is high. SAS is a possible risk factor for CAD. Sleep apnea monitoring should be performed in patients with CAD, and early diagnosis of CAD will be beneficial to the treatment of coronary heart disease.