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目的:优选丹桃颗粒的壳聚糖絮凝剂澄清工艺,并与乙醇沉淀法、离心法进行比较。方法:以水浸出物收率、苦杏仁苷及芍药苷保留率为综合评价指标,选择壳聚糖加入量、絮凝时药液温度、药液pH为考察因素,通过正交试验优选丹桃颗粒的壳聚糖絮凝剂澄清工艺,并与乙醇沉淀法和离心法进行比较,确定最佳除杂工艺。结果:优选的壳聚糖絮凝剂澄清工艺为加入10%药液量的1%壳聚糖澄清剂,药液pH 6.0,50℃保温;苦杏仁苷、芍药苷保留率均>89%,水浸出固形物量约下降19%,整体优于乙醇沉淀法和离心法。结论:壳聚糖絮凝剂澄清法可作为丹桃颗粒提取液的除杂工艺,该工艺合理可行、稳定可靠,符合工业化生产要求。
Objective: To optimize the chitosan flocculant clarification process of Dan peach granules, and compare with ethanol precipitation method and centrifugal method. Methods: With the yield of water extract, the retention rate of amygdalin and paeoniflorin as the comprehensive evaluation indexes, the dosage of chitosan, the temperature of the liquid during flocculation and the pH of the liquid were selected as the investigation factors. By orthogonal test, Chitosan flocculant clarification process, and compared with ethanol precipitation method and centrifugal method to determine the best impurity removal process. Results: The optimal chitosan flocculant clarification process was adding 1% chitosan clarifier with the volume of 10%, the pH value was 6.0 and the temperature was kept at 50 ℃. The retention rates of amygdalin and paeoniflorin were both above 89% Leaching solids decreased by about 19%, the overall better than ethanol precipitation and centrifugation. Conclusion: The chitosan flocculant clarification method can be used as impurity removal technology for Dan-peach extract. The process is reasonable and feasible, stable and reliable, and meets the requirements of industrialized production.