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复方新诺明系由磺胺甲基异恶唑(SMZ)加抗生素增效剂甲氧苄氨嘧啶(TMP)组成,对伤寒、急慢性支气管炎、肺炎,布氏杆菌病、菌痢、尿路感染等疾病有一定的疗效,在临床上应用较广泛。但SMZ系磺胺类药物,具有泌尿道损害及过敏反应,偶有恶心、呕吐、头晕、头痛、乏力等不良反应。TMP亦具有引起皮疹、白细胞减少、肝肾功能损害等不良反应。所以二药配伍后,虽其抗菌效力可大增,其不良反应亦增强。近来
The compound cotrimoxazole is composed of sulfamethoxazole (SMZ) and antibiotic synergist trimethoprim (TMP), and is effective against typhoid fever, acute and chronic bronchitis, pneumonia, brucellosis, bacillary dysentery, urinary tract Infection and other diseases have a certain effect, is widely used in clinical practice. But SMZ is a sulfa drugs, with urinary tract damage and allergic reactions, occasional nausea, vomiting, dizziness, headache, fatigue and other adverse reactions. TMP also has caused rash, leukopenia, liver and kidney dysfunction and other adverse reactions. Therefore, compatibility of two drugs, although its antimicrobial efficacy can be greatly increased, its adverse reactions are also enhanced. recently