论文部分内容阅读
目的:研究高血压患者脉压水平与下肢动脉粥样斑块形成的关系。方法:选取106例原发性高血压患者,根据彩色多普勒超声检查下肢动脉粥样斑块情况分为两组,斑块组64例,无斑块组42例,检测血脂和尿酸变化,监测24h动态血压,比较两组间性别构成、年龄、血脂和尿酸水平、24h平均收缩压、舒张压及脉压差水平有无统计学差异。结果:两组之间年龄分布存在明显的统计学差异(p<0.001);斑块组PP明显高于无斑块组(P=0.003);年龄与脉压之间呈正相关(r=0.301,p=0.005)。结论:脉压增大可能是导致下肢动脉斑块形成的危险因子,降低脉压对高血压患者靶器官的保护可能起重要的作用。
Objective: To study the relationship between pulse pressure and the formation of atherosclerotic plaque in patients with hypertension. Methods: 106 patients with essential hypertension were divided into two groups based on color Doppler ultrasonography for detecting atherosclerotic plaque in lower limbs: 64 cases in plaque group and 42 cases in plaque-free group. The changes of blood lipid and uric acid, The ambulatory blood pressure was monitored 24 hours. The gender composition, age, blood lipid and uric acid level, 24h mean systolic pressure, diastolic pressure and pulse pressure difference were compared between the two groups. Results: There was a significant difference in age distribution between the two groups (p <0.001); PP in plaque group was significantly higher than that in plaque group (P = 0.003); age was positively correlated with pulse pressure (r = 0.301, p = 0.005). CONCLUSION: Increased pulse pressure may be a risk factor for the formation of arterial plaque in lower extremities. Reducing pulse pressure may play an important role in the protection of target organs in hypertensive patients.