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宿主细胞蛋白-蛋白磷酸酶1(PP1)是人类免疫缺陷病毒1型(human immunodeficiency virus-1,HIV-1)转录的调节因子之一,参与HIV-1转录。脱磷酸化cyclinT1依赖性激酶9(CycT1-dependent kinase9,CDK9)或RNA聚合酶ⅡC末端区(RNAPII CTD)以增强Tat诱导的转录。本文综述了PP1在HIV-1转录过程的作用及其抑制剂研究进展。
Host cell protein-protein phosphatase 1 (PP1) is one of the transcription factors of human immunodeficiency virus-1 (HIV-1), which is involved in HIV-1 transcription. Dephosphorylation of Cyclin1-dependent kinase 9 (CDK9) or RNA polymerase II C-terminal region (RNAPII CTD) enhances Tat-induced transcription. This review summarizes the role of PP1 in transcription of HIV-1 and the progress of its inhibitors.