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目的比较胸腺肽联合干扰素及单用干扰素在改善慢性乙型肝炎(简称慢乙肝)患者肝功能和抗病毒方面的疗效。方法对72例慢乙肝应用胸腺肽联合干扰素抗病毒治疗.对36例慢乙肝单用干扰素抗病毒治疗。观察这两种药物在改善肝功能和抗病毒方面的疗效并进行比较。结果72例慢乙肝经胸腺肽联合干扰素治疗6个月,联合组与干扰素组对肝功能的影响无显著差异,P>0.05;联合组与干扰素组血清HBeAg/抗HBe转换率方面差异显著P<0.01。结论胸腺肽联合干扰素有协同作用,明显优于单用干扰素。
Objective To compare the efficacy of thymosin combined with interferon and interferon alone in improving liver function and antiviral activity in patients with chronic hepatitis B (chronic hepatitis B). Methods 72 patients with chronic hepatitis B were treated with thymosin combined with antiviral therapy and 36 patients with chronic hepatitis B were given antiviral therapy with interferon alone. The efficacy of the two drugs in improving liver function and antiviral activity was observed and compared. Results 72 cases of chronic hepatitis B with thymosin combined with interferon for 6 months, the combination group and interferon group had no significant difference in liver function, P> 0.05; combination group and interferon serum HBeAg / anti-HBe conversion rate was significantly different P <0.01. Conclusions Thymosin combined with interferon has a synergistic effect, which is obviously better than that of interferon alone.