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食源性急性菌例２９例中２８例大便培养为弗氏２ａ志贺氏菌。经２天吡哌酸加ＴＭＰ短程快速治疗，２９例无一例治愈。依据药敏试验改用环丙沙星治疗，其中１１例感染严重者先予静脉点滴，每１２小时２００ｍｇ，１～２天，症状好转即改口服，每１２小时２５０ｍｇ。另１８例口服，疗程均为４天。用药后，平均退热时间１．３２天，大便次数恢复正常时间平均２．１０天，大便常规正常时间平均２．８６天，２８例大便培养阳性者，平均阴转时间３．２５天。经１疗程治疗后，全部治愈。用药期间，１１例出现轻度恶心、纳差，停药后消失。本文报道的弗氏２ａ志贺氏菌所致临床症状重，对吡哌酸、诺氟沙星耐药率高达９６．４３％和４２．８６％，而对环丙沙星则敏感。
In 29 cases of food-borne acute cases, stool culture was Shigella flexneri in 28 cases. After 2 days of piperacillin plus TMP short-term rapid treatment, 29 cases were cured. According to drug sensitivity test to ciprofloxacin treatment, of which 11 cases were infected with severe intravenous drip, every 12 hours 200mg, 1 to 2 days, the symptoms improved to oral, every 12 hours 250mg. Another 18 cases of oral, treatment are 4 days. After treatment, the average antipyretic time was 1.32 days, stool frequency returned to normal on average 2.10 days, stool routine normal average of 2.86 days, 28 cases of stool culture positive, the average time of 3.25 days negative conversion. After a course of treatment, all cured. During the medication, 11 patients with mild nausea, anorexia, disappeared after stopping. The clinical symptoms caused by Shigella flexneri reported in this paper were heavy, and the resistance rates to pipemidic acid and norfloxacin were as high as 96.43% and 42.86%, respectively, but sensitive to ciprofloxacin.