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目的探讨达英35(炔雌醇环丙孕酮片)联合二甲双胍预处理治疗多囊卵巢综合征(PCOS)合并不孕患者的临床疗效。方法选取2012年1月-2014年1月医院收治的PCOS合并不孕患者60例随机分为联合用药观察组和对照组各30例,对照组给予达英35治疗,观察组给予达英35和二甲双胍治疗,并比较两组疗效。结果观察组治疗后的FSH、LH和T等性激素指标均明显低于对照组,2年内妊娠率为50.0%明显高于对照组,差异均有统计学意义(P<0.05);两组治疗期间均无严重不良反应发生。结论达英35联合二甲双胍治疗PCOS合并不孕可明显改善患者性激素指标,提高临床妊娠率,且不良反应少、安全性高,值得临床推广应用。
Objective To investigate the clinical effect of Da Ying 35 (ethinyl estradiol cyproterone tablets) combined with metformin pretreatment on patients with polycystic ovary syndrome (PCOS) complicated with infertility. Methods Sixty patients with PCOS complicated with infertility admitted to our hospital from January 2012 to January 2014 were randomly divided into the control group (30 cases) and the control group (35 cases), the control group Metformin treatment, and compare the two groups curative effect. Results After treatment, the indexes of FSH, LH and T in the observation group were significantly lower than those in the control group. The pregnancy rate was 50.0% within 2 years, which was significantly higher than that of the control group (P <0.05) No serious adverse reactions occurred. Conclusion Da-ying 35 combined with metformin in the treatment of PCOS with infertility can significantly improve the patient’s sex hormone markers, improve clinical pregnancy rate, and less adverse reactions, high safety, worthy of clinical application.