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据国家自然科学基金委员会2002年1月9日报道,上海市肿瘤研究所赵新泰研究员等人在国家自然科学基金支持下,发现染色体17p13.3区在肝癌细胞中有高频率杂合性缺失,并开展了染色体17p13.3区基因克隆及与肝癌相关性的研究,成功地克隆到了一个新基因。根据肿瘤抑癌基因的定义及该基因在肝癌组织中的特性,他们把它命名为肝癌抑制因子1(Hepatocellular Carcinoma Suppressor 1,简称 HCCS1)。该结果发表在2001年第61期《癌症研究》(Cancer Research)上。寻找与肿瘤相关的基因特别是新的抑癌基因,是近年来肿瘤基因研究的热点。此次发现的基因的 cDNA 全长约2000碱基对,共有18个外显子,基因组
According to the National Natural Science Foundation of China reported on January 9, 2002, Shanghai Cancer Institute Zhao Xintai and other researchers supported by the National Natural Science Foundation found that the chromosome 17p13.3 region in the liver cancer cells have high frequency heterozygosity and A chromosome 17p13.3 region gene cloning and liver cancer research, successfully cloned a new gene. According to the definition of tumor suppressor gene and its characteristics in liver cancer, they named it HCCS1. The result was published in Issue 61, 2001, Cancer Research. Looking for tumor-related genes, especially the new tumor suppressor gene, is a hot spot in tumor gene research in recent years. The cDNA of this discovery is about 2000 base pairs in length with a total of 18 exons and genomes