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急性肾功能衰竭(acute rRenal failure,ARF)是指肾小球滤过功能在数小时至数周内迅速降低而引起的以水、电解质和酸碱平衡失调及以含氮废物蓄积为主要特征的一组临床综合征。近年来,轻型、单一肾脏衰竭的存活率已有明显提高,但危重患者,特别是创伤、大手术后或严重感染患者的病死率仍高达50%以上,预防ARF发生、早期诊断及终止其病情的进展,是当前ARF临床和研究工作中的一个重要方向。研究发现肾内各种细胞受损而出现的代谢、功能以及形态结构的紊乱是ARF时GFR持续降低、内
Acute renal failure (ARF) refers to the rapid decline in glomerular filtration over a period of hours to weeks, resulting in the imbalance of water, electrolytes and acid-base balance and the accumulation of nitrogenous waste A group of clinical syndromes. In recent years, the survival rate of light and single renal failure has been significantly improved. However, the mortality rate of critically ill patients, especially trauma, major surgery or severe infection is still over 50%, preventing the occurrence of ARF, early diagnosis and termination of their condition Is an important direction in the current ARF clinical and research work. The study found that various cell damage in the kidney metabolism, function, and morphological disorder is GFR GFR continued to decline, within