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近年来，医药科技成果斐然，新疗法、新药物层出不穷。但伴发而来的医源性（包括滥用药物引发的药源性）疾病亦日趋严重，令人防不胜防。有人指出“滥用药物已成为社会公害”，此言实不为过。许多不争的事实表明，滥用药物不仅使药物的不良反应增多，导致药源性疾病发生频率增加，而且药物的滥用、误用还会掩盖一些严重疾病的症状而延误诊治，同时不规范用药亦培育了耐药性病原体，除此还造成资源的严重浪费以及伪劣药品充斥市场，并且加重了个人和公费医疗的经济负担等等。滥用药物问题的产生固然有其社会因素的影响，如药品生产者、销售者乃至医疗单位受经济利益的起动，更有临床医生缺乏对药物不良反应及其危害性的认识、缺乏合理用药的知识等原因。此类问题同样存在于本刊的一些读者。由于目前药品种类繁多，使许多临床医生在应用中产生诸多困惑，尤其对一些新药的药理、药性、配伍禁忌、不良反应及用药经验缺乏了解，因此许多读者来信求助于本刊。为了满足本刊读者的需求，使其尽可能多地掌握正确用药、合理用药的方法，在临床工作中使人民群众免遭药害之苦，本刊特此组织了“临床合理用药”的大型笔谈。在笔谈中，各位专家告诫人们怎样合理用药，如哪些疾病或哪些情况时应慎用或不用哪些药物，哪?
In recent years, the achievements in medical science and technology have been impressive. New treatments and new drugs are emerging in an endless stream. However, the iatrogenic (including the drug-induced drug-induced) abuse of drugs has become increasingly serious and unmanageable. Someone pointed out that “abuse of drugs has become a public nuisance”, which is not an exaggeration. Many irrefutable facts show that drug abuse not only increases the adverse reactions of drugs but also increases the frequency of drug-induced diseases, and the misuse of drugs can also mask the symptoms of some serious diseases and delay the diagnosis and treatment, nor does it regulate the use of drugs The emergence of drug-resistant pathogens has also resulted in serious waste of resources and the flooding of markets of counterfeit medicines, increasing the financial burden on individual and public health care and so forth. Although the emergence of drug abuse problems has its social factors, such as the start-up of economic interests by drug manufacturers, distributors and even medical units, there is a lack of knowledge of adverse drug reactions and harmful effects by clinicians and the lack of rational drug use And other reasons. Such issues also exist in some of our readers. Due to the wide variety of medicines currently available, many clinicians have been confused in their applications. In particular, they have not understood the pharmacology, pharmacodynamics, incompatibility of contraindications, adverse reactions and medication experience of some new drugs. Therefore, many readers have come to this article for assistance. In order to meet the needs of readers of this journal, it is necessary to grasp as much as possible the methods of proper medication and reasonable medication so as to protect the people from the harmful effects of medicine in clinical work. The journal has organized a large-scale written “clinical rational medication” . In the written discussion, the experts warned people how to rationalize the use of drugs, such as what diseases or conditions should be used with caution or not, which?