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目的:探讨大豆异黄酮活性组分对阿尔茨海默病(AD)小鼠脑海马神经元及血脂水平血清过氧化物歧化酶(SOD)活性的影响。方法:取10个月龄的小鼠,以D-半乳糖和三氯化铝建立AD模型小鼠,用不同剂量的大豆异黄酮活性组分灌胃治疗15 d,眼球取血测定血清总胆固醇(TC)、三酰甘油(TG)和高密度脂蛋白胆固醇(HDL-c)水平及SOD活力;观察脑内海马组织切片神经元细胞的形态改变。结果:与模型对照组相比治疗组血清TC、TG含量显著降低(P<0.01)、血清HDL-c含量显著升高(P<0.01)、SOD活力显著提高(P<0.01),显剂量效应关系;海马区神经元细胞数量也显著增多,形态改善。结论:大豆异黄酮活性组分能有效调节AD小鼠的血脂的水平,显著提高血清SOD的活性。
OBJECTIVE: To investigate the effect of active components of soybean isoflavones on the activity of serum superoxide dismutase (SOD) in hippocampal neurons and blood lipids of mice with Alzheimer’s disease (AD). METHODS: Ten-month-old mice were used to establish AD model mice with D-galactose and aluminum trichloride. Gavage treatment with different doses of soy isoflavones was performed for 15 days. Blood samples were taken from the eyeball to determine serum total cholesterol. (TC), triglyceride (TG) and high-density lipoprotein cholesterol (HDL-c) levels and SOD activity; observed morphological changes of neurons in hippocampal slices of the brain. Results: Compared with the model control group, serum TC and TG levels in the treatment group were significantly lower (P<0.01), serum HDL-c levels were significantly increased (P<0.01), SOD activity was significantly increased (P<0.01), and significant dose effect was observed. Relationships; The number of neuron cells in the hippocampus was also significantly increased, and the morphology was improved. Conclusion: Soybean isoflavones active ingredients can effectively regulate the blood lipid levels in AD mice and significantly increase the activity of serum SOD.