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目的 探讨对肺结节病治疗副作用小、且有一定疗效的新方法。方法 对 10例Ⅱ期肺结节病患者进行了吸入表面激素治疗的观察。治疗方法为二丙酸倍氯米松 (必可酮或必酮碟 ) 60 0～ 12 0 0 μg d、分 2～ 3次吸入 ,疗程 8～ 12个月。其中 6例为单纯吸入表面激素治疗 ;另外 4例 ,2例为开始用强的松口服 ,2～ 3个月后改为吸入表面激素序贯治疗 ,2例为开始用表面激素治疗 ,后改为强的松口服 3～ 4个月 ,又改为吸入激素序贯治疗。以临床症状、胸部X线、血气或肺功能等检查观察疗效。结果 10例病人临床症状均有改善 ,血氧分压均有提高 ,X线 9例改善 ,其中 1例停药 1年后复发。 3例肺功能异常者 ,2例改善 ,1例无变化。结论 吸入表面激素疗法治疗肺结节病 ,对临床症状、血氧分压及胸部X线有改善作用 ,作为口服激素的序贯治疗 ,有进一步研究的价值
Objective To explore a new method of treating lung sarcoidosis with little side effects and a certain curative effect. Methods 10 patients with stage Ⅱ pulmonary sarcoidosis were treated with inhaled hormone therapy. The treatment method is beclometasone dipropionate (ketorolac or propoxyproline) 60 0-1200 μg d for 2 or 3 inhalations for 8-12 months. Among them, 6 cases were treated by pure inhalation of the surface hormones. In the other 4 cases, 2 cases started oral prednisone, 2 to 3 months later, they were sequentially treated with inhaled surface hormones, 2 cases started treatment with surface hormone, For prednisone oral 3 to 4 months, and then changed to inhaled hormone sequential treatment. To clinical symptoms, chest X-ray, blood gas or pulmonary function tests to observe the effect. Results The clinical symptoms of 10 patients were improved, the partial pressure of oxygen was increased, X-ray improved in 9 cases, of which 1 patient relapsed after 1 year of withdrawal. 3 cases of abnormal lung function, 2 cases improved, 1 case no change. Conclusions Inhaled topical hormone therapy for pulmonary sarcoidosis has the effect of improving clinical symptoms, partial pressure of oxygen and chest X-ray. As the sequential treatment of oral hormones, it has the value of further research