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报道一种简易改良骨髓活检块GMA塑料包埋法，结合冷固定、冷脱水、冷浸渍和冷包埋，于4℃真空下聚合的有效制冷系统，不仅容许缓慢聚合而又使许多细胞抗原因聚合过程中过度产热所致热损伤的防止而得以保留。为研究同一切片内骨髓细胞形态和免疫组化分析提供了一种有效诊断工具。CML患者切片以CD八h单抗染色后于不同成熟阶段之巨核细胞之胞浆均呈强阳性反应，方法简单而无需昂贵设备，适于以取得之小块骨髓在任何血液实验室中常规进行。
Reported a simple and improved bone marrow biopsy block GMA plastic embedding method, combined with cold fixation, cold dehydration, cold dipping and cold embedding, an effective refrigeration system for polymerization under vacuum at 4°C, not only allows slow polymerization but also causes many cell resistance Prevention of thermal damage due to excessive heat production during the polymerization process is preserved. To provide an effective diagnostic tool for studying bone marrow cell morphology and immunohistochemical analysis in the same section. CML patients stained with CD8 monoclonal antibody showed strong positive reaction in the cytoplasm of megakaryocytes at different stages of maturation. The method is simple and does not require expensive equipment. It is suitable for routinely conducting small bone marrow obtained in any blood laboratory. .