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目的：探讨一氧化氮（ＮＯ）水平与妊高征的关系。方法：采用Ｇｒｅｉｓ法及放射免疫技术测定５０例妊高征患者（妊高征组），３０例正常晚期孕妇（晚孕组）外周血及脐静脉血ＮＯ及其第二信使环磷酸鸟苷（ｃＧＭＰ）水平，并以２５例健康未孕妇女（未孕组）作对照。结果：①妊高征组与晚孕组外周血ＮＯ及ｃＧＭＰ水平无显著差异（Ｐ＞００５），但均显著高于未孕组（Ｐ＜００５）；②妊高征组尤其中、重度妊高征脐静脉血ＮＯ及ｃＧＭＰ水平均显著高于晚孕组（Ｐ＜００５），且与收缩压及舒张压呈正相关关系（ｒ值分别为０４６，０５２；０４５，０５０，Ｐ＜００５）。结论：妊高征患者外周血ＮＯ及ｃＧＭＰ水平无明显变化，脐静脉血ＮＯ及ｃＧＭＰ水平升高，提示ＮＯ并非是妊高征发生、发展的根本原因，可能是脐－胎盘循环对血压升高、胎盘缺氧的代偿性反应。
Objective: To investigate the relationship between nitric oxide (NO) level and pregnancy-induced hypertension. Methods: The serum levels of NO and its second messenger cyclic guanosine monophosphate (CIN) in 50 patients with PIH and 30 normal pregnant women (late pregnancy group) were determined by Greis method and radioimmunoassay. cGMP) levels, and 25 healthy non-pregnant women (non-pregnant group) as a control. Results ① There was no significant difference in NO and cGMP levels between the PIH group and the late pregnancy group (P> 0.05), but both were significantly higher than those in the non-pregnant group (P <005) The levels of NO and cGMP in umbilical venous blood of patients with moderate and severe PIH were significantly higher than those of the second trimester pregnancy (P <005), and positively correlated with systolic and diastolic blood pressure (r = 0.46,052 ; 045, 050, P <005). Conclusion: No significant changes of NO and cGMP levels in peripheral blood of patients with PIH and elevated levels of NO and cGMP in umbilical venous blood suggest that NO is not the underlying cause of development and progression of PIH, which may be due to the elevated blood pressure of umbilical-placental circulation , Placental hypoxia compensatory response.