论文部分内容阅读
[目的]探讨湿疹患者的心理状况、血清神经肽及二者的相关性。[方法]用症状自评量表(SCL-90)作为心理状况调查问卷,测评126例湿疹患者躯体化、强迫、人际关系、恐怖、抑郁、焦虑、敌对、偏执和精神病性等9个症状因子;并对湿疹患者血清及40例正常健康组血清应用双抗体夹心ELISA法检测其P物质(SP)水平,并用放射免疫测定法检测其血管活性肠肽(VIP)水平。[结果]湿疹患者与正常常模的SCL-90评分比较,在躯体化、人际关系、恐怖、抑郁、焦虑、偏执等因子的评分差异有统计学意义(P﹤0.05);湿疹患者血清SP及VIP水平均较正常健康组明显增高(P﹤0.001);上述因子评分与血清SP及VIP水平有正相关性。[结论]湿疹患者存在着较多的心理问题,并可能通过神经肽对湿疹的发生发展起着促进作用。
[Objective] To explore the psychological status of patients with eczema, serum neuropeptides and their correlation. [Methods] Nine symptom factors such as somatization, compulsion, interpersonal relationship, horror, depression, anxiety, hostility, paranoid and psychosis in 126 patients with eczema were measured using the SCL-90 as a psychological status questionnaire . Serum samples of patients with eczema and 40 healthy controls were assayed for serum substance P (SP) by sandwich enzyme-linked immunosorbent assay (ELISA) and the level of vasoactive intestinal peptide (VIP) was determined by radioimmunoassay. [Results] Compared with SCL-90 scores of eczema patients and normal norm, there were significant differences in somatization, interpersonal relationship, horror, depression, anxiety and paranoid scores (P <0.05) VIP levels were significantly higher than normal healthy group (P <0.001); The above-mentioned factor score and serum SP and VIP levels have a positive correlation. [Conclusion] There are many psychological problems in patients with eczema and may promote the occurrence and development of eczema through neuropeptides.