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目的初步研究骨科骨质疏松患者骨密度(BMD)和血尿酸的关系。方法 65例骨质疏松患者根据其血尿酸水平分为低尿酸组(血尿酸<420μmol/L,n=37)和高尿酸组(血尿酸≥420μmol/L,n=28)。对入组患者进行实验室测定和人体测量、骨密度测定等。结果两组合并不良事件(脆性骨折、高血压、糖尿病、冠心病、脑血管事件)比较差异无统计学意义(P>0.05);低尿酸组血尿酸(282.56±73.08)μmol/L显著低于高尿酸组(501.86±79.98)μmol/L(P<0.05),低尿酸组腰椎骨密度、股骨颈BMD低于高尿酸组(P<0.05),L1~4的骨密度和血尿酸水平呈现显著正相关(P<0.05)。左股骨颈的骨密度和血尿酸水平呈现正相关,差异无统计学意义(P>0.05)。结论血尿酸是腰椎骨密度的保护性因素,骨质疏松患者的血尿酸水平值得在临床工作中予以关注。
Objective To study the relationship between bone mineral density (BMD) and serum uric acid in patients with orthopedic osteoporosis. Methods 65 cases of osteoporosis were divided into low uric acid group (serum uric acid <420μmol / L, n = 37) and high uric acid group (serum uric acid≥420μmol / L, n = 28) according to their uric acid level. Enter the group of patients for laboratory and human measurement, bone mineral density determination. Results There were no significant differences in the two groups of combined adverse events (brittle fracture, hypertension, diabetes, coronary heart disease, cerebrovascular events) (P> 0.05). The serum uric acid (282.56 ± 73.08) μmol / L in low uric acid group was significantly lower than (501.86 ± 79.98) μmol / L (P <0.05). BMD of lumbar vertebrae and BMD of femoral neck were lower in hyperuricemia group than those in hyperuricemia group (P <0.05). BMD and serum uric acid level in L1-4 group were significantly higher Positive correlation (P <0.05). Left femur neck bone mineral density and serum uric acid levels showed a positive correlation, the difference was not statistically significant (P> 0.05). Conclusion Serum uric acid is a protective factor in lumbar spine bone mineral density. Serum uric acid level in patients with osteoporosis deserves attention in clinical practice.