Construction of exogenous multiple epitopes of helper T lymphocytes and DNA immunization of its chim

• 作 者: Wen-JunGao Xiao-MouPeng Dong-Y
• 机 构: DepartmentofInfectiousDiseases,DepartmentofInfectiousDiseases,DepartmentofInfectiousDiseases
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2004年20期
• 关键词: 外生性 多发性 抗原 辅助机车T 淋巴细胞 DNA 免疫学 质粒 HBV pre-S2/S基因 HTL 基因表达
• 基金项目: Supported by the National Natural Science Foundation of China,NO.39970677 and the Science Foundation of Guangdong Province,NO.99M04801G

AIM: To design and construct an exogenous multiple epitope of helper T lymphocytes (HTL), and to evaluate its effect on anti-HBs response through DNA immunization. METHODS: Artificial HTL epitope, PADRE and four other HTL epitopes from different proteins