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目的 探讨激光动力学治疗 (PDT)支气管肺癌的临床疗效。方法 应用德国产光敏剂photosan 3,2mg/kg静注后 4 8h在内镜下用德国产CERALASPDT 6 30Laser 2 0 0J/cm照射病变部位 ,必要时 72～ 96h内再重复 1至 2次。结果 2 3例患者近期疗效良好。CR 11例 ,肿瘤消失 ,管腔通畅 ;SR 9例 ,6例仅见有少许肿物残留 ,3例肿瘤缩小一半以上 ;MR 2例 ,因肿瘤堵塞管腔无法插入光纤所致 ;1例隆突转移癌PDT治疗后第 3天因肿瘤坏死脱落致大出血而死亡。结论 PDT治疗支气管肺癌具有疗效确切、副作用小、可重复治疗的特点 ,尤其对不能手术的气管、支气管腔内生长为主的中央型肺癌、支气管肺癌术后残端复发及有放、化疗禁忌证的患者具有较好的临床应用价值
Objective To investigate the clinical efficacy of laser kinetic therapy (PDT) in bronchogenic carcinoma. Methods German photosensitizer photosan 3,2mg / kg intravenously 48h after endoscopic treatment with German-made CERALASPDT 6 30Laser 200J / cm irradiation lesions, if necessary, 72 ~ 96h and then repeat 1 to 2 times. Results 23 cases of patients with good immediate effect. CR 11 cases, the tumor disappeared, the lumen patency; SR 9 cases, 6 cases saw only a few residual tumor, 3 cases of tumor reduced by more than half; MR 2 cases, due to tumor plugging the lumen can not be inserted due to optical fiber; Metastatic cancer PDT died on day 3 after hemorrhage due to tumor necrosis. Conclusions PDT has the characteristics of definite curative effect, small side effect and repeatable treatment, especially for central lung cancer with inoperation-free tracheobronchial growth, recurrence of residual stump after bronchial lung cancer and contraindication with radiotherapy and chemotherapy Of patients have good clinical value